Artificial sweeteners may be derived through manufacturing of cinnamon substitute extracts or processed by chemical synthesis. Sugar substitute products are commercially available in various forms, such as small pills, powders, and packets. Approved artificial sweeteners do not cause cancer.

This section needs additional citations for verification. Please help improve this article by adding citations to reliable sources. As a result, much less sweetener is required and energy contribution is often negligible. If the sucrose, or other sugar, that is replaced has contributed to the texture of the product, then a bulking agent is often also needed.

Cyclamates are used outside the United States, but are prohibited from being used as a sweetener within the United States. The majority of sugar substitutes approved for food use are artificially synthesized compounds. These are, in general, less sweet than sucrose but have similar bulk properties and can be used in a wide range of food products. Sometimes the sweetness profile is fine-tuned by mixing with high-intensity sweeteners. Allulose is a sweetener in the sugar family, with a chemical structure similar to fructose.