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Brain tumor, breast cancer, colon cancer, congenital heart disease, heart arrhythmia. They often form on feet and toes or hands and fingers. If you’re healthy, you don’t need treatment for corns and calluses unless they cause pain or you don’t like how they look. For most people, simply removing the source of the friction or pressure makes corns and calluses disappear. They can vary in size and shape and are rarely painful. Corns and calluses are not the same thing. Corns are smaller and deeper than calluses and have a hard center surrounded by swollen skin.

They can be painful when pressed. Hard corns often form on the top of the toes or the outer edge of the small toe. Soft corns tend to form between the toes. Calluses are rarely painful and tend to develop on pressure spots, such as the heels, the balls of the feet, the palms and the knees. They may vary in size and shape and are often larger than corns. If you have diabetes or poor blood flow, seek medical care before self-treating a corn or callus. Learn more about Mayo Clinic’s use of data.