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Take to the stars and explore a brand new cosmic universe! Available now on iOS and Android! All trademarks referenced herein are the properties of their respective owners. They are the consequence of multiple mutational processes, including the intrinsic slight infidelity of the DNA replication machinery, exogenous or endogenous mutagen exposures, enzymatic modification of DNA and defective DNA repair.

This summary includes the mutational profile, proposed aetiology and tissue distribution of each signature, as well as potential associations with other mutational signatures and how the signature has changed during iterations of analysis. Currently, four different variant classes are considered, resulting in the following sets of mutational signatures. They can be identified using mutational signatures, due to their unique mutational pattern and specific activity on the genome. This is illustrated in the figure below using a framework of 6 classes of single base substitutions, and three distinct mutational processes, whose respective strengths vary throughout a patient’s life.